mercury poisoning is a debilitatind desease

Systemic inflammation also causes reduced protein synthesis through inhibition of the Akt/ mTOR pathway. The increased production of cytokines induces proteolysis and breakdown of myofibrillar proteins. NF-κB is a known regulator of the genes that encode cytokines and cytokine receptors. This mechanism involves the formation of reactive oxygen species leading to upregulation of the transcription factor NF-κB. TNF has been shown to have a direct catabolic effect on skeletal muscle and adipose tissue through the ubiquitin proteasome pathway. Inflammatory cytokines appear to play a central role including tumor necrosis factor (TNF) (which is also nicknamed 'cachexin' or 'cachectin'), interferon gamma and interleukin 6. The exact mechanism in which these diseases cause cachexia is poorly understood, and likely is multifactorial with multiple disease pathways involved. Cachexia can also be the result of advanced stages of cystic fibrosis, multiple sclerosis, motor neuron disease, Parkinson's disease, dementia, tuberculosis, multiple system atrophy, mercury poisoning, Crohn's disease, trypanosomiasis, rheumatoid arthritis, and celiac disease as well as other systemic diseases. Ĭongestive heart failure, AIDS, chronic obstructive pulmonary disease, and chronic kidney disease are other conditions that often cause cachexia. Prevalence of cachexia rises in more advanced stages and is estimated to affect 80% of terminal cancer patients.

Those with upper gastrointestinal and pancreatic cancers have the highest frequency of developing a cachexic symptom. About 50% of all cancer patients develop cachexia. The term is from Greek κακός kakos 'bad' and ἕξις hexis 'condition'.Ĭachexia can be caused by diverse medical conditions, but is most often associated with end-stage cancer, known as cancer cachexia. Cachexia is associated with increased mortality and poor quality of life. Cachexia can improve with treatment of the underlying illness but other treatment approaches have limited benefit. Diagnosis of cachexia can be difficult due to the lack of well-established diagnostic criteria. In contrast to weight loss from inadequate caloric intake, cachexia causes mostly muscle loss instead of fat loss. Systemic inflammation from these conditions can cause detrimental changes to metabolism and body composition. A range of diseases can cause cachexia, most commonly cancer, congestive heart failure, chronic obstructive pulmonary disease, chronic kidney disease, and AIDS. Sudden weight loss, altered eating signalsĬachexia ( / k ə ˈ k ɛ k s i ə/ ) is a complex syndrome associated with an underlying illness, causing ongoing muscle loss that is not entirely reversed with nutritional supplementation. Oncology, Internal Medicine, Physical Medicine and Rehabilitation Processes and mechanisms related to cancer-associated cachexia

Mercury poisoning is a debilitatind desease